Research

Photoorganocatalysis

In recent years Cross-Dehydrogenative coupling have become one of the major areas of improvement in Organic Chemistry. The C-H activation of ethers or amines using stechiometric oxidant such as MnO2, DDQ or catalytic procedures using transition metal catalysts and stechiometric peroxides have become a useful tool to functionalize these common known as inert positions. However these approachs have several drawbacks such as huge generation of waste due the use of stechiometric oxidants and the use of transition metals. In our research group we proposed as a green alternative to these methodologies the use organic dyes and oxygen as oxidant. We plan to couple this oxidation process with organocataluytic methodologies to obtain interesting products and processes.

For example we developed a phosphoramidation catalyzed by organic dyes:

Related Publications:

1- “Organophotocatalytic synthesis of phosphoramidates” Marta Meazza, Agnieszka Kowalczuk, Luke Shirley, Hao Guo* and Ramon Rios*.Adv. Synth. Catal. 2016, 358, 719-723.

2- “Organocatalytic Cross Dehydrogenative copling for Synthesis of Fluorinated Compounds” Luke Shirley, Victor Ceban, Marta Meazza and Ramon Rios. ChemistrySelect 2016, 1, 13-15.

3- “Catalyst-Free Photocyclopropanation of Dibromomalonates with Alkenes: An Approach to Multisubstituted Cyclopropanes” Yanbin Zhang, Yong An, Jing Sun, Aishun Ding, Yu Wang,* Ramon Rios,* and Hao Guo*; Tetrahedron Lett. 2015, 56, 6499-6502.

4- “Catalyst-Free Photooxidation of Triarylphosphines under Aerobic Conditions” Aishun Dinga, Yu Wang, Ramon Rios, Jing Sun, Han Li, and Hao Guo,* J. Saudi Chem. Soc. 2015, 19, 706-709.